Composer's note:

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Angiogenesis is the process by which the human body creates new blood vessel branches. This is a fascinating capability, as it is both lethal and lifesaving in different contexts.

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In the case of cancer, angiogenesis around and into tumors supplies the nutrients necessary for accelerated tumor growth, and a goal in cancer treatment is to target and block receptors that trigger the growth of new blood vessels that feed tumors.

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On the other hand - in the case of heart disease - if an arterial blockage in the heart develops slowly enough, the restricted blood flow acts as a cue to the body to stimulate angiogenesis around a blockage. There are documented cases where patients have a total coronary blockage, but have not had a major heart attack: the body has healed itself, growing new tiny blood vessels around a blockage and allowing the blood to reach the deprived tissue. New treatments for cardiovascular blockages include targeted, controlled stimulation of this incredible natural process.

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This piece focuses on the latter form of angiogenesis, offering a musical depiction of the sinister nature of a growing blockage that the body then overcomes. Coronary angiogenesis is a miracle, and the piece ends with a meditative soundworld that reflects the peace of knowing that healing is possible.

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